The Chiefs‘ Patrick Mahomes is just as efficient at home as he is on the road.He gets the same results Kyle Juszczyk Jersey , too.After winning his first three starts, all away from Arrowhead Stadium, the second-year pro finally made his regular-season home debut Sunday. Mahomes responded by torching San Francisco’s banged-up pass defense for 314 yards and three touchdowns in a 38-27 victory over the 49ers.Mahomes now has 13 touchdown passes without an interception, breaking the NFL record for TD passes in the first three weeks of a season. Peyton Manning threw 12 to start the 2013 campaign.Mahomes’ touchdown passes to Chris Conley, Demetrius Harris and Sammy Watkins , along with a pair of TD runs by Kareem Hunt, helped Kansas City (3-0) race to a 35-7 lead late in the first half.Few leads are safe against the Chiefs’ porous defense, though.The 49ers (1-2) rallied behind running backs Matt Breida and Alfred Morris Tom Rathman Color Rush Jersey , who kept gouging the Chiefs’ defensive front, and Jimmy Garoppolo, who threw for 251 yards and two scores . It was Garoppolo’s 11-yard pass to Marquis Goodwin early in the third quarter that started the comeback, and Morris scored on a short touchdown run later in the quarter to make it 35-24.After the Chiefs tacked on a field goal early in the fourth to extend their lead, the 49ers came back with a grinding, 17-play drive that wiped out more than half the period. But it ended in a strange sequence that began with Garoppolo taking a hard hit from Steven Nelson along the sideline. Garoppolo easily could have stepped out of bounds, but instead he was crushed on his throwing shoulder and had to leave.C.J. Beathard came in and threw what appeared to be a fourth-down touchdown pass to George Kittle, but it was wiped out by offensive pass interference.There was only 5:17 left https://www.49ersfanshop.com/Pierre-Garcon-Jersey , but rather than go for it on fourth-and-goal at the Kansas City 25, 49ers coach Kyle Shanahan elected to kick a field goal — keeping it a two-possession game.San Francisco proceeded to kick it deep rather than try an onside kick. The Chiefs picked up a first down on a penalty, and Hunt churned his way for two more first downs to put the game away.The 49ers have not won in Arrowhead Stadium since Dec. 26, 1982.FOSTER’S FRUSTRATION49ers LB Reuben Foster had a rough return from a two-game suspension for violating the league’s personal conduct and substance abuse policy. Foster was hit with a personal foul for hitting Mahomes as the QB was sliding in the first half, Kelce beat him in pass defense, and the young linebacker left early in the fourth quarter when he was shaken up on a tackle.INJURIES49ers: The defensive backfield was in tatters by the fourth quarter. CB Richard Sherman left with a calf injury, FS Adrian Colbert hurt his ankle and backup CB Tarvarius Moore left with a wrist injury. SS Jaquiski Taylor was already inactive with a shoulder injury.Chiefs: LB Dee Ford left with a groin injury in the fourth quarter. … Conley briefly left with a right ankle injury, though he returned to make his TD catch. … SS Eric Berry (heel) remained inactive for the third straight week. He has not practiced since early in camp.UP NEXT49ers: Play the Chargers in Los Angeles next Sunday.Chiefs: Visit the AFC West-rival Broncos next Monday night.___ TV: CBSTime: 4:05 p.m.SANTA CLARA Earl Mitchell Jersey , Calif. (AP) — Jimmy Garoppolo has started his tenure with San Francisco better than any quarterback has done with a new team.The player who brought hope to the 49ers after three-plus years of struggles in San Francisco will be in for his toughest test yet this week.Garoppolo and the 49ers (4-10) host the playoff-bound Jacksonville Jaguars (10-4) on Sunday, facing their punishing defense that leads the NFL in fewest points allowed, most sacks and lowest yards per play against.More Jacksonville Jaguars newsJets’ Darnold throws 3 more picks in 29-15 loss at JaguarsRams get CB Jalen Ramsey from Jaguars for 3 draft picksBridgewater now 4-0 as starter after Saints top Jaguars 13-6Jaguars once elite defense struggles as Gardner Minshew, DJ Chark build chemistryLeonard Fournette runs for career-high as Jaguars mount comeback to beat Broncos“I look forward to it a lot, for our whole team,” coach Kyle Shanahan said. “I do believe that they have as much qualities as anyone that it takes to win a Super Bowl; a top defense, a very good running game, a good offense Malcolm Smith Color Rush Jersey , good special teams. When you see a team like that on tape that you believe has that ability, it’s a good thing, it’s a good challenge for your team to go against them and see where you’re at.”The Niners have done quite well since making Garoppolo the starter earlier this month in Chicago. He joined Hall of Famer Y.A. Tittle as the only 49ers quarterbacks to win his first three starts with the franchise and is the first quarterback to do that with any team while throwing for at least 1,000 yards in those games, according to the Elias Sports Bureau.That performance is not lost on the Jaguars, who can clinch their first division title since 1999 with a win.“He is a really good NFL quarterback,” coach Doug Marrone said. “We know that. That’s on film. That’s on tape. That’s not something we have to fabricate or make him seem better than he is. He’s as good as it gets right now for what’s going on around the league.”While Garoppolo has played as well as any quarterback the past three weeks, the Jaguars have been tops in the league on defense all year with a unit modeled after the one that has been so dominant for years in Seattle.Jacksonville leads the NFL in several defensive categories thanks in part to a quartet of Pro Bowlers in defensive end Calais Campbell https://www.49ersfanshop.com/Robbie-Gould-Jersey , defensive tackle Malik Jackson, cornerbacks Jalen Ramsey and A.J. Bouye.“A lot of teams are adapting to this and so you see it all over the league now. Seattle started it and now teams are adapting it,” Garoppolo said. “I think the players that they have make it unique. They have very talented players on every level of the defense. It’s going to be a good challenge for us.”Here are some other things to watch:RED-ZONE WOESPerhaps the only area where Garoppolo has struggled has been in finishing drives. The 49ers have scored on 18 of 28 non-kneeldown drives since he took over as starter earlier this month. Only three of those scores were touchdowns. San Francisco has scored TDs on just three of 10 red-zone trips in those games, the fourth-worst rate in the league during that span.“It’s probably one of the toughest areas in football offensively to execute,” Garoppolo said. “Everything has to go perfect down there.”BORTLES’ BOOSTThe Jaguars have gotten pretty strong play from their quarterback of late as well. Blake Bortles is the first Jacksonville quarterback to have three straight games with at least two TD passes and no interceptions. Bortles is averaging 301 yards passing during that span and leads the NFL with a 128.6 passer rating in December.“Any time you have a defense play the way they do and any time you have the number one running game in the NFL, that makes a lot of things easier on a quarterback,” Shanahan said. “Not to take anything away from him, but he’s doing exactly what he needs to do and he’s making plays doing it.”GOOD FOR GOODWINThe biggest beneficiary of Garoppolo’s arrival has probably been receiver Marquise Goodwin Reuben Foster Jersey , who has 24 catches for 319 yards the past three weeks. Goodwin has topped the 100-yard mark the past two weeks and can become the first San Francisco player to do it three in a row since Jerry Rice had a four-game streak in 1995. The prolific numbers come as little surprise to Marrone, who coached Goodwin during his first two seasons in Buffalo in 2013-14.“I loved him,” Marrone said. “He’s the fastest player I’ve ever seen on a field. And I’ve been around some fast players.”TRAVELING BLUESThe Jaguars clinched their first playoff berth since 2007 last week but have gone even longer without winning on the West Coast. Jacksonville has lost eight straight games in the Pacific Time Zone and most of them haven’t been close. The Jaguars have been outscored by 20.9 points per game in that span since their last win out west on Jan. 2, 2005, at Oakland.131<button class="view-gallery">View Gallery</button> Gallery:Jacksonville Jaguars cheerleadersReinhold Matay-USA TODAY Sports | Reinhold Matay